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It enhances repair processes by promoting angiogenesis (partly through VEGF upregulation), reducing inflammation, and mobilizing progenitor cells

Piraccini BM, Parente GL, Varotti E, Tosti A

PKC contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

Berberine also induces apoptosis via the mitochondrial pathway, promoting the release of cytochrome c from mitochondria, activating caspase-8, 9, and subsequent caspase-3 cascades, and triggering apoptosis by inhibiting the expression of Bcl-2 while increasing pro-apoptotic proteins (85)

Just S, Mondot S, Ecker J, Wegner K, Rath E, Gau L, et al

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