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34 Stratakis CA, Kirschner LS, Carney JA

That's a weight-loss drug demonstrating outcomes beyond the scale, in one of the highest-risk populations in medicine

While these strategies remain experimental, they offer hope for patients with recurrent or refractory disease (Plotkin & Blakeley, 2022)

The main reason that it is difficult is because it takes so long

This evidence provides a connection between impaired energy metabolism and neurodegeneration in PD and HD and suggests that stimulating mitochondrial biogenesis by PGC-1 might be a promising strategy for the prevention of PD

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