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Mechanistically, metformin upregulated the expression and membrane localization of glucose transporter 1 (GLUT1) by downregulating thioredoxin-interacting protein (TXNIP) expression

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PMID 16284435

2020;12(10):e11169

This is a top-down approach to weight management because the drug acts directly on the central nervous system, essentially telling the brain to quiet down its hunger signals before they ever reach the conscious decision-making level