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Clinical trials confirm that monotherapy (4.5 mg weekly subcutaneous injection) reduces body weight by 10.8% in obese patients (BMI 30) over 26 weeks, significantly outperforming placebo [4]

It acts on the ghrelin/GHS-R1a receptor in the pituitary to trigger a rapid, dose-dependent burst of growth hormone release

Financial support and sponsorship This work was supported by National Institutes of Health grants R01 AG057381 (Ladiges and Darvas, co-PI's) and R01 AG057381 (Ladiges PI)

Dopamine modulates mitochondrial function in viable SH-SY5Y cells possibly via its interaction with complex I: relevance to dopamine pathology in schizophrenia