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Similar content being viewed by others Introduction Lung cancer remains the leading cause of global cancer-related mortality, accounting for over 1.5 million annual deaths annually [1, 2]

Furthermore, mechanical ventilation is a risk factor for cerebral inflammation and brain injury due both to the pulmonary inflammatory cascade, which migrates systemically to the brain, and to hemodynamic instability for the reduction in cardiac output and high pulmonary resistance caused by the distension of alveoli and compression of pulmonary capillaries 132

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While most patients tolerate NAD + well , mild side effects may occur, and they include: Warmth or flushing

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