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Clinical Nutrition Open Science, 38 , 3342

GPx1 deficiency was found to promote mitochondrial dysfunction in response to stress, such as I/R and doxorubicin exposure in cardiomyocytes and in trauma models in brain, whereas GPx1 overexpression limited the mitochondrial respiratory stress [41, 43, 44, 114]

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Once a vial has been pierced, mark the date of first puncture and discard 28 days later in line with standard multiple-dose vial practice, and never use beyond the printed expiry even if the 28 days have not elapsed