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No randomized controlled trial has tested sublingual tirzepatide for weight loss, blood sugar control, or any other outcome

Abbreviations GLP-1 RA: Glucagon-like peptide-1 receptor agonist MACE: Major adverse cardiovascular events HR: Hazard ratio CI: Confidence interval HER: Electronic health record ICD: International statistical classification of diseases and related health statistical classification of diseases and related health problems CPT: Current procedural terminology BMI: Body mass index MRA: Mineralocorticoid receptor antagonist ACE inhibitor: Angiotensin converting enzyme inhibitor ARB: Angiotensin II receptor blocker SGLT2 inhibitor: Sodium-glucose co-transporter 2 GFR: Glomerular filtration rate HbA1c: Hemoglobin A1c STROBE: Strengthening the reporting of observational studies in epidemiology SD: Standard deviation PS: Propensity score SMD: Standardized mean difference References Nichols, G

typical dose 1.75 mg (1750 mcg) administered 45 min before activity [1]

doi: 10.1073/pnas.1612177114

In a phase 2a trial specifically examining metabolic dysfunction-associated steatotic liver disease, the 8 mg retatrutide group showed 81.7% mean relative reduction in liver fat, and the 12 mg group showed 86% reduction

Gastrointestinal Side Effects Over Time Nausea, vomiting, diarrhea, and constipation are the most common side effects of GLP-1 therapy