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Both MAPK/ERK1/2 and the pro-survival PI3K/Akt pathways are stimulated by IGF-I, IGF-2, and activated IGF-1R in cumulus granulosa cells (60)

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Analyses were based on the in-trial period, which was the time from randomization to the end-of-trial visit, death, withdrawal of consent or last contact with a trial site, whichever occurred first

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Complementary to this, additional biological function scoring was performed using GSVA, with genesets for each biological function obtained from the AmiGO 2 web portal [1]