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Sorrentino G, Crispino P, Coppola D, De Stefano G
However, patients are unlikely to see this immediately after starting semaglutide
(2021) Cell Rep 36 : 109374-109374 PubMed: 34260945 Search on PubMed DOI: Primary Citation Related Structures: 7KI0, 7KI1 PubMed Abstract: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity
Figure from Rossing et al NDT 2023 Primary Outcome This was a composite of time of first occurrence of: Onset of kidney failure (persistent eGFR 28 days or initiation of long-term KRT, kidney transplantation) Persistent 50% reduction in eGFR from baseline Death from kidney or CV causes Secondary Outcomes Confirmatory secondary outcomes were analyzed hierarchically
doi:10.1056/nejmoa2306963 2