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In patients with pre-existing gastroparesis, this can produce severe nausea, vomiting, and dangerous delays in drug absorption for co-administered oral medications (including contraceptives and thyroid replacement)

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2023 Ludvik B, Giorgino F, Jodar E et al (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

Psyllium husk supplements (Metamucil) work differentlythey absorb water and add bulk to stools, making them a gentler alternative to anti-diarrheal drugs

US Food and Drug Administration, Silver Spring, MD