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Of note, in combined FOXO1/3- knockout or FOXO1/4- knockout animals, tumor incidence was slightly increased [32]

Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function

These data points are compatible with the notion that dual-pathway stimulation of pituitary somatotrophs may produce a markedly greater IGF-1 increase than either peptide alone

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