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Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease

6.2.2 Intermittent induction and dose optimization Although ferroptosis holds the potential to induce immunogenic cell death (ICD), its intense lipid peroxidation and uncontrolled release of intracellular components, if not temporally regulated, may lead to excessive inflammation, immune cell exhaustion, or organ damage (147)

Most available evidence comes only from laboratory experiments or animal studies , which cannot reliably predict real effects in the human body

Poor nutrition A diet lacking in protein, sulfur-rich vegetables, or antioxidants limits the bodys ability to produce and maintain glutathione

Food Chem Toxicol 2012;50:444960

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