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Rutin protects hair cells and spiral ganglion neurons from cisplatin-induced ototoxicity by reducing ROS production after cisplatin exposure, activating PI3K/AKT signalling and inhibiting the JNK/p38/MAPK signalling pathway ( 3.1.7 Genistein (genistein/strongylisoflavone, GST) GST is a phytoestrogen found in large quantities in soybeans, GST increases the levels of antioxidant enzymes and decreases the levels of oxidant parameters, preventing cisplatin ototoxicity ( 3.1.8 Formononetin (FMNT) FMNT is a natural flavonoid found in large quantities in herbs such as Angelica sinensis and Astragalus membranaceus.FMNT reduces ROS overload by activating the PI3K/AKT-Nrf2 signalling pathway and its downstream antioxidant genes, decreases the c-caspase-3/caspase-3 ratio ( 3.1.9 Epigallocatechin-3-gallate (EGCG) and epicatechin EGCG, a polyphenol abundant in green tea extract, is a STAT1 inhibitor.EGCG prevents cisplatin cytotoxicity through anti-apoptotic and antioxidant effects ( in vitro and ex vivo ( Epicatechin (EC) is a minor component of green tea
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Form & Analytical Testing This research peptide blend is supplied in lyophilized powder form , a standard preparation method used to preserve peptide stability during storage and transport
Ideal for adjusting to time zone changes, shift work, or irregular sleep patterns
Koth, C
