topiramate and glp 1 Updates on Anti-Obesity Medications in Children Adolescents What are the differences between

Rapid, drug-assisted weight loss is genuinely transformative

10.1016/j.bcp.2021.114578 [DOI] [PubMed] [Google Scholar] Yang S., Zhao X., Zhang Y., Tang Q., Li Y., Du Y., et al

This amount of weight loss has not been accomplished before with medical therapy

Research focus: Cellular senescence, stress-induced aging models, and senescence-associated secretory phenotype (SASP) biology

A recent clinical trial in type 2 diabetes patients with CVDs following captopril treatment (12.5 mg/day, P.O for 3 months) found a significant improvement in plasma GSH levels and a concomitant decline in lipid peroxidation [241]

Surgical Risk: The use of GLP-1s can slow stomach emptying, which may pose risks (e.g., aspiration) during anesthesia if the medication is not paused prior to surgery