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It will therefore be important to define the epitope specificity and serum neutralization activity in these animal models, and potential T cell mechanisms will need to be excluded before enhanced immunopathology can be attributed to antibody mechanisms

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This attachment might make the receptor change its shape, which could start cell signals, mainly those involving G-proteins

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The complex binds copper through the N-terminal amine, the imidazole nitrogen of histidine, and the deprotonated amide nitrogen of the Gly-His peptide bond, forming a stable square-planar coordination geometry

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