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While GLP-1 microdosing is ideal for maintenance, longevity, and overall wellness support, those with a significant weight-loss goal may be better suited for a standard GLP-1 dose

Nor do we know how they might interact with any licensed drugs a person is taking

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A 2024 Diabetes, Obesity and Metabolism study on a small-molecule NNMT inhibitor found it dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and suppressed hyperinsulinaemia in obese mice (PMID 39161060) [6]

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What good monitoring looks like Routine follow-up with your diabetes doctor Retinal monitoring based on your baseline eye disease severity Faster eye review if symptoms appear or worsen Coordination between endocrinology and ophthalmology if retinopathy is active For some patients, this may mean standard annual follow-up