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Note: Because AOD-9604 does not affect glucose metabolism or IGF-1, monitoring requirements are simpler than with growth hormone therapy

Excessive caloric intake increases FFA load to the liver to a point that the ability of the hepatocytes to oxidize FFA or re-esterify to TG and secrete very low-density lipoproteins (VLDL) is overwhelmed

Kessova, I

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There was more stable production over time in these systems compared to the non-selected controls, although the production under selection did not surpass the original control levels

Following this study period, the patients were randomized into two arms, either continuing tirzepatide therapy or continuing with placebo (85)