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To this end, high-fat-diet (HFD) feeding in mice has been shown to induce beta-cell-like changes in the electrical profile of a subset of alpha-cells ( ARX and DNMT1 , exhibit increased expression of markers of beta-cell fate, such as MAFA , and furthermore, we find this effect in induced in human islets in response to treatment with a GLP-1R agonist ( DNMT1 and ARX expression in alpha-cells from islets of T1DM donors were associated with increased expression of beta-cell markers, PDX1 and NKX6