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In the present review, we made an attempt to summarize the major aspects of the function of the l-arginine-NO system, from cellular l-arginine uptake to l-arginine catabolism by NOS to NO, arginase to l-ornithine and downstream metabolites, arginine methylation, and l-arginine-NO related oxidative stress

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59 , 60 Likewise, it counteracts consequences of the chronic abuse (drinking alcohol for 3 months) 58 such as chronic gastric lesions 51 or liver lesions with portal hypertension

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