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Some researchers transition to maintenance-dose tirzepatide (typically 2.5-5mg weekly) indefinitely rather than stopping completely

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NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

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(See here: Individual results may vary, and these medications should only be used under the guidance of a qualified healthcare professional