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VitD deficiency is linked to diminished bone mineralization and heightened cortical bone loss, which exacerbates the development and progression of OP in the elderly, hence increasing bone fragility (30)

doi: 10.4102/jir.v6i1.84

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He J, Qian YC, Yin YC, Kang JR, Pan TR

In contrast, while pharmacokinetic studies have characterized the rapid plasma clearance of cynaroside after intravenous administration, its oral bioavailability and ability to cross the bloodbrain barrier remain poorly understood (Huang et al., 2014)

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