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Developed by the pharmaceutical company Eli Lilly, Zepbound offers a novel approach to weight management by combining the effects of two hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia

A 2 min baseline reading was taken before addition of test compound, AF568-GLP-1 (Kd concentration, 3.16nM, determined previously) was added 10 min later, and the measurement continued for 20 min

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