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The procedure is generally very well tolerated and not described as painful or excruciating

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95% CI, 0.58 to 2.60) for pulmonary aspiration associated with GLP-1 agonist use, which was not statistically significant

It is notable that even if the pathway is absent, ascorbate is present in some of these compartments, albeit in more oxidised form (Conklin et al

The STEP trials evaluated semaglutide and showed average weight reductions of around 15% over 68 weeks, while SURMOUNT trialsfocusing on tirzepatide, a dual GIP/GLP-1 receptor agonistdemonstrated even greater reductions, with participants losing up to 21% of their body weight over 72 weeks (Note: GIP = Glucose-dependent insulinotropic polypeptide)