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To gain deeper insight into the activity of individual DUBs, we used activity-based probes to enrich cysteine protease DUBs and their identification using a mass spectrometry (MS) approach

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A similar subtle gray matter pathology has also been described in the MS brain

The findings, published 23 May in Translational Psychiatry, are intriguing but should be reproduced in a larger sample, says Stephen Moss, professor of neuroscience at Tufts University in Boston, who was not involved in the study