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Retatrutide's glucagon activity can also transiently affect heart rate and glycemic dynamics variables that become harder to interpret when a second agonist is layered on

doi: 10.1210/jcem.81.3.8772550 97 LeeJHFangCLiXWuCSNohJYYeXet al

[1] [2] Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist that works through similar mechanisms

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Sulfur burps are one of the most talked-about side effects of GLP-1 medications like semaglutide and tirzepatide, even though GI effects like bloating, nausea, and constipation are more common

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