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Because tirzepatide works by dramatically suppressing appetite through GLP-1 and GIP hormone pathways, patients often eat significantly less without realizing that low protein intake forces the body to break down lean muscle tissue for fuel

The additional 2-2.5 kg of loss comes predominantly from fat tissue, reflecting the lipolytic and anti-lipogenic mechanism

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The metabolic impact of tirzepatide throughout its weekly cycle is far more gradual and sustained than the sharp peaks and troughs that would be needed to meaningfully shift daily energy expenditure

And to anyone out there who feels trapped in the grip of obesity, know that there is help

Fat takes the longest to digest, and when your stomach is already moving slowly, adding hard-to-digest food makes everything worse