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The stomach pain associated with Ozempic use stems primarily from its pharmacological action on the gastrointestinal system

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Conversely, tolerance-maintaining pathways become epigenetically repressed, such as IL-2 transcriptional silencing and FOXP3 locus instability, where insufficient TSDR demethylation undermines Treg stability (135,136)

The underlying mechanisms also include altering the composition and balance of the gut microbiome, which further influence the process of neurodegeneration via the gut-brain axis (Fig

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Q: What is the difference between MT-2 and MT-1