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In the SURPASS-2 trial, which directly compared tirzepatide to semaglutide 1 mg for type 2 diabetes, nausea rates were 17-22% for tirzepatide across all three dose levels (5 mg, 10 mg, and 15 mg) versus 18% for semaglutide 1 mg

TGF- activity on HGF/c-MET is regulated by MAPK/ ERK and AKT signaling To clarify the downstream signaling events resulting in suppression of c-MET pathway activity, we first analyzed the involvement of SMAD proteins, the central effectors of TGF- canonical signaling