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Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits NAD + levels and mitochondrial homeostasis have been linked to symptoms of aging as well as other pathologies, including cancer, progressive muscle diseases, and neurodegenerative diseases

L., Wijayasinghe, N., & Norwood, P

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10.2215/CJN.03950417 112 MeyerT

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The enhanced fat oxidation capacity matters most when there is a metabolic demand for it, and physical activity creates that demand much more effectively than caloric restriction alone