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For patients with Medicare prescription coverage, an approved application is valid for the current calendar year only

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Hormone and Metabolic Modulators added to the Prohibited List, including elacestrant (added as an anti-estrogen), S519 and S597 (examples of insulin-mimetics), and MOTSc (an example of an AMP-activated protein kinase activator)

Because of this, Eli Lillys own prescribing information for Mounjaro and Zepbound tells patients to use a barrier method of birth control, or switch to a nonoral method, for four weeks after starting the drug and for four weeks after every dose increase (Mounjaro prescribing information)

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For patients not currently on either empagliflozin or metformin, the recommended starting Synjardy dosage is typically a lower strength taken twice daily