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TYRs catalyse the hydroxylation of monophenols to o -diphenols (EC 1.14.18.1, monophenolase activity) as well as the subsequent oxidation of o -diphenols to their corresponding o -quinones (EC 1.10.3.1, diphenolase activity) 1,4 , whereas COs catalyse only the latter reaction, unable to react with monophenolic substrates (Fig