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Further, ebselen follows the analogous catalytic steps as that of native GPx enzymes, and the activation energies for the ebselen-catalyzed and native enzyme-catalyzed GPx reactions are 55 kJ/mol and 36.5 kJ/mol, respectively [78]

Possible role of IGF-1-binding proteins

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Finally, some commonly used drugs (e.g., glucocorticoids and GLP-1RAs) can also affect intra-portal insulin levels that modulate the GH/IGF-I axis either by increasing or decreasing hepatic GH sensitivity, as reflected by the discordant GH and IGF-I levels

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