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In unstimulated state, the activation loop (a-loop), containing the critical tyrosine (Y) residues 1131, 1135 and 1136, behaves as a pseudosubstrate that blocks the active site

However, with increasing temperatures, the abundance of proteins decreases due to temperature thresholds for protein functionality

REFERENCES All information presented above is derived from in vitro experiments, animal studies, and other preclinical research models

however, excessive production or insufficient clearance leads to oxidative and nitrosative stress, which can damage lipids, proteins, and nucleic acids

This leads to a condition called hypogonadism