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As noted, donation of the methyl group from SAM results in the formation of SAH (Figure 2)

CBS and CSE, both of which are pyridoxal 5-phosphate (PLP)-dependent enzymes, function sequentially in the transsulfuration pathway, converting homocysteine and serine into cystathionine and subsequently cysteine (Figures 2 a,b) ( 2 S by utilizing alternative substrates, namely, a combination of cystine and homocysteine for CBS and either cysteine or homocysteine for CSE ( in vitro (Figure 2c) ( in vivo

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Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models

Lazarova N, Krumova E, Stefanova T, Georgieva N, Angelova M

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