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On other hand, patients with CFS exert significant effort to perform their daily activities, resulting in enhanced neural activation which may boost the production of pro-inflammatory cytokines and reactive oxygen and nitrogen species (Lange et al
10.1038/s41467-021-27385-3 28 DubuquoyL.LouvetA.LassaillyG.TruantS.BoleslawskiE.ArtruF.et al (2015)
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Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex
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