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It was found that the OPFRs only increased the level of ROS and methemoglobin at very high concentrations: at 500 g/mL, they were found to induce morphological changes and ultimately cause lytic cell death and PS externalization

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Since drugs in this pipeline target and enhance autophagy, a cellular degradation pathway which is critical for the functioning of all cells and declines with age, they also represent exciting candidates for prevention of cognitive decline and other degenerative diseases of aging