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Physiol Rev 2001

doi: 10.1016/s0165-0173(00)00018-7

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It also supports respiratory health by thinning mucus, which is relevant for those detoxifying from cigarette smoke exposure

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This matters because: Natural GH release is pulsatile (bursts followed by troughs) Continuous GH elevation can lead to receptor desensitization Pulsatile release maintains receptor sensitivity The pattern matches your body's circadian rhythm This is why timing and dosing frequency matter with Ipamorelinyou're working with your body's natural rhythms, not against them