The reductions observed in glycated haemoglobin levels with tirzepatide at a dose of 5 mg, 10 mg, and 15 mg were 2.01% points, 2.24% points, and 2.30% points, respectively, compared to 1.86% points with semaglutide at a dose of 1 mg
Personal testimonials of feeling better are meaningless scientifically
One subsequent analysis has estimated that 7.9 million individuals meet the SELECT trial criteria in the US: Among these individuals, treatment with semaglutide could prevent about 190 000 cardiovascular events in 5 years. If each eligible patient received semaglutide at a retail price of $16 188 per year, the total cost would amount to $127 billion per year. The authors of SELECT noted that: Potentially less costly alternatives for reducing obesity and CVD risk include lifestyle counseling, dietary fasting, and alternative pharmacological weight loss approaches
Manifesting as open sores in the lining at the top of the small intestine just beneath the stomach, duodenal ulcers form when the mucous lining of the intestine gets damaged
Figure was created by the author
AAPS PharmSciTech, 21 , 299
