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However, no Phase II or Phase III randomized controlled trials have been published as of 2026, meaning the full safety profile particularly long-term effects, drug interactions, and dose-dependent risks remains incompletely characterized

[DOI] [PubMed] [Google Scholar] 98.Abdeen G, le Roux CW

Both compounds show remarkable liver fat reduction and metabolic improvements that extend well beyond the scale

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A 16-week randomized trial compared once-daily SC injected liraglutide vs placebo in patients with schizophrenia who incurred weight gain and prediabetes after taking olanzapine or clozapine

Average weight loss reaches 12 pounds per week during the early months, with cumulative loss of 1015% body weight over 612 months