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A study by Teichman and colleagues, published in Journal of Clinical Endocrinology and Metabolism, showed impressive results

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The mice were randomly assigned to experimental groups as follows: control group: saline-treated db/m mice( n = 6)

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(1993) investigated IGF-1 LR3 in animal models and demonstrated that its reduced IGFBP binding resulted in enhanced bioactivity compared to native IGF-1 at equivalent doses [2]