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The key supplements in Huberman's core supplement regimen include foundational supplements like Vitamin D, Omega-3 fatty acids, and Magnesium, as well as cognitive enhancers like Alpha-GPC, L-Tyrosine, and Phenylethylamine (PEA), and sleep optimizers like Magnesium L-Threonate, Theanine, and Apigenin

PMID 21901217

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However, there is still a lack of direct evidence for these mechanisms except bile acid metabolism