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The microbiome and the immune system are critically intertwined

For example, a randomized controlled trial in 2014 involving about 370 patients with osteoarthritis in the knee found that curcumin was just as effective as ibuprofen for reducing inflammation, swelling, and pain but with far fewer gastrointestinal side effects

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Although children have a higher percentage of detectable antibodies from natural infection than adults, natural immunity on a population level is insufficient in protecting kids, the ACIP said, as natural immunity protection is random and there is no way to protect who will get strong protection and who will get no protection from it