Oxidized thioredoxins (Trx ox ) are reduced (Trx red ) by thioredoxin reductases (TrxR), utilising NADPH as a cofactor [7]
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The use of Drosophila bring to the study of oxidative liver injury many advantages, including ease of genetic manipulation, availability of genetic mutants and constructs, ease of germ-free generation, relatively short lifespan, amenability to high-throughput screening, and overall cost relative to murine models 40
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