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Recent studies have identified that the mitochondrial AAA protease Lon interacts with multiple protein partners to promote the generation of ROS, which in turn activates the NF-B signaling axis, amplifying downstream oncogenic pathways and contributing to tumor development and immune evasion [58]

Xgeva was later approved by the FDA to treat giant cell tumor of the bone, for hypercalcemia of malignancy refractory to bisphosphonate therapy and for the prevention of skeletal-related events in patients with multiple myeloma

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In the absence of these specific conjugates, we sought to examine whether ChaC1 could be inhibited by other glutathione conjugates