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The diagnosis of VDKB in an infant is indicated when the prothrombin time (PT) is found to be at least 4 times longer than the control value even though the infants platelet count and fibrinogen levels are normal

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[DOI] [Google Scholar] 27.Upadhyay V.K., McSweeney P.L.H., Magboul A.A.A., Fox P.F

Ascorbic Acid is also needed for: Carnitine synthesis Tyrosine synthesis and catabolism Serotonin (neurotransmitter) synthesis Other hormone and neurotransmitter synthesis6 The figure below shows how ascorbic acid is needed for dopamine hydroxylase, which ultimately produces the hormone epinephrine

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Those with underlying mitochondrial or enzymatic disorders may be more susceptible to adverse reactions due to impaired NAD metabolism