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Clin Exp Pharmacol Physiol 42(6):632639

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Recent findings also revealed concerns with the loss of skeletal muscle mass when taking GLP-1RAs with some studies reporting up to 50% of weight loss being due to decreases in muscle mass

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Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice

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