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The 1 mg pen uses approximately 2.68 mg/mL

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and 0.33g of the compound 1 was dissolved in 100mL of acetonitrile, and then added dropwise to the above mixture to react at 0 to 5 for 3 hours, the resulting reaction solution was adjusted to pH 5.0 with trifluoroacetic acid, and then 2 times of purified water was added thereto, and centrifugation was carried out to obtain a solid compound 2, the liquid chromatogram of FIG

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The pre-filled pen devices are calibrated to deliver specific doses in milligrams, eliminating the need for manual calculation or conversion by patients