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Most studies have been on animals or dishes of cells in the lab

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CHOP also prompt the expression of GADD34 (69), which complexes with protein phosphatase 1 (PP1) to induce the dephosphorylation of eIF2, thus forming a negative feedback loop

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J Biomater Sci Polym Ed 19(8):969988 Akeson AL et al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1