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p -value 0.3462]), and semaglutide (RR 1.9181 [95% CI 0.2354, 7.8184

Generic manufacturers increasingly use IPR as a first-move option against delivery-system patents, particularly formulation patents on extended-release products where the prior art landscape includes academic publications on polymer matrix technology that may anticipate or render obvious the challenged claims

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This may reflect receptor downregulation from continuous use

DPP-IV inhibitors also decrease glucagon secretion, and in concert with a rise in plasma insulin, lead to a reduction in basal hepatic glucose production [16]