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Mechanistically, berberine inhibits the expression of murine double-minute 2 (MDM2) and SIRT2, downregulates the purinergic P2X7 receptor (P2X7R) and p-ERK1/2 expression, and increases the expression of dual specificity phosphatase 6 (DUSP6) to effectively mitigate cisplatin-induced renal histopathological damage and improve renal function

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